Promethazine hydrochloride and codeine phosphate syrup is indicated for your short-term reduction of coughs and higher respiratory signs or symptoms connected with allergy or maybe the common chilly.
Cautiously measure the dose using a Unique measuring machine/spoon. Don't make use of a house spoon because you may well not get the correct dose.
Reevaluate individuals with unresponsive cough in five times or quicker for probable underlying pathology, such as international overall body or reduce respiratory tract condition.
Promethazine is contraindicated in comatose states, As well as in men and women known to be hypersensitive or to own had an idiosyncratic reaction to promethazine or to other
Maintain a listing of every one of the products you utilize (which include prescription/nonprescription medicines and herbal products) and share it with your health practitioner and pharmacist. Will not get started, halt, or change the dosage of any medicines without your medical professional's approval.
The concomitant usage of Promethazine with Codeine Oral Remedy with all cytochrome P450 3A4 inducers or discontinuation of the cytochrome P450 3A4 inhibitor may well bring about reduced codeine amounts, increased norcodeine ranges, and less metabolism by way of 2D6 with resultant reduced morphine levels. This may be connected with a lessen in efficacy, and in a few individuals, could cause indicators and signs or symptoms of opioid withdrawal.
No formal experiments are actually executed in patients with hepatic impairment so the pharmacokinetics of Promethazine with Codeine Oral Answer In this particular client inhabitants are unknown.
Diligently evaluate the dose using a Particular measuring device/spoon. Will not make use of a residence spoon simply because you may not get the right dose.
This isn't an entire list of possible Unintended effects. When you observe other Unintended effects not get more info listed higher than, Get hold of your medical doctor or pharmacist.
Problems OF USE: The knowledge In this particular database is intended to supplement, not substitute for, the know-how and judgment of Health care professionals. The information just isn't intended to address all possible uses, Instructions, safety measures, drug interactions or adverse results, nor should really it's construed to point that usage of a particular drug is Safe and sound, suitable or efficient for you personally or any individual else.
Drug interactions may well modify how your medicines work or raise your danger for major Unwanted effects. This doc will not comprise all achievable drug interactions.
Carcinogenicity experiments had been carried out with promethazine hydrochloride. Two-12 months experiments in F344/N rats and B6C3F1 mice had been carried out to evaluate the carcinogenic opportunity of promethazine hydrochloride. No evidence of tumorigenicity was observed in male and female rats at promethazine hydrochloride oral doses as many as 33 mg/kg/working day for five times/7 days (about equivalent to 10 periods the MRHD with a mg/m2 foundation).
Codeine has lower plasma protein binding with about 7 to twenty five% of codeine certain to plasma proteins. Codeine passes the blood brain barrier as well as the placental barrier. Tiny quantities of codeine and its metabolite, morphine, are transferred to human breast milk.
The pharmacokinetics of Promethazine with Codeine Oral Option has not been characterised in sufferers with renal impairment. Codeine pharmacokinetics could be altered in patients with renal failure. Clearance can be lowered and also the metabolites may accumulate to Considerably larger plasma concentrations in clients with renal failure as compared to clients with regular renal purpose.